Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.A376E

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.A376E
c.1127C>A
Surrounding Variants
1 paper
NM_003749.3
p.A376V
c.1127C>T
1 paper
NM_003749.3
p.A375A
c.1125G>C
1 paper
NM_003749.3
p.A375V
c.1124C>T
1 paper
NM_003749.3
p.A375P
c.1123G>C
1 paper
NM_003749.3
p.A378V
c.1133C>T
1 paper
NM_003749.3
p.S388G
c.1162A>G
1 paper
NM_003749.3
p.A364T
c.1090G>A
1 paper
NM_003749.3
p.G393W
c.1177G>T
1 paper
NM_003749.3
p.P398L
c.1193C>T
1 paper
NM_003749.3
p.P398H
c.1193C>A
1 paper
NM_003749.3
p.A353V
c.1058C>T
5 papers
NM_003749.3
p.A353T
c.1057G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."