Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.S342W

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_003749.3
p.S342W
c.1025C>G
Surrounding Variants
1 paper
NM_003749.3
p.S342L
c.1025C>T
1 paper
NM_003749.3
p.R341insFs
c.1022_1023ins4
1 paper
NM_003749.3
p.S342fs
c.1024_1025fs
1 paper
NM_003749.3
p.R341R
c.1023C>A
1 paper
NM_003749.3
p.R343L
c.1028G>T
1 paper
NM_003749.3
p.R340C
c.1018C>T
2 papers
NM_003749.3
p.A348V
c.1043C>T
1 paper
NM_003749.3
p.T336K
c.1007C>A
1 paper
NM_003749.3
p.A349T
c.1045G>A
1 paper
NM_003749.3
p.S334R
c.1002C>G
1 paper
NM_003749.3
p.S334R
c.1002C>A
1 paper
NM_003749.3
p.T350P
c.1048A>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."