Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.A280A

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.A280A
c.840G>A
Surrounding Variants
1 paper
NM_003749.3
p.A280V
c.839C>T
1 paper
NM_003749.3
p.Q281P
c.842A>C
1 paper
NM_003749.3
p.Q281H
c.843G>T
1 paper
NM_003749.3
p.Q281H
c.843G>C
1 paper
NM_003749.3
p.H284H
c.852C>T
1 paper
NM_003749.3
p.D276E
c.828C>G
1 paper
NM_003749.3
p.D276E
c.828C>A
1 paper
NM_003749.3
p.D275D
c.825C>T
1 paper
NM_003749.3
p.T286S
c.856A>T
1 paper
NM_003749.3
p.T286I
c.857C>T
1 paper
NM_003749.3
p.A274A
c.822G>C
1 paper
NM_003749.3
p.A274T
c.820G>A
UCSC Genome Browser·Imprint·Privacy·Terms·Feedback·Email Updates·

Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."