Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.N232Y

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.N232Y
c.694A>T
Surrounding Variants
1 paper
NM_003749.3
p.N232I
c.695A>T
2 papers
NM_003749.3
p.V229L
c.685G>T
1 paper
NM_003749.3
p.V229L
c.685G>C
2 papers
NM_003749.3
p.E234delFs
c.700_701delTC
2 papers
NM_003749.3
p.F228L
c.684C>G
2 papers
NM_003749.3
p.F228L
c.684C>A
1 paper
NM_003749.3
p.C233_E234delFs
c.699_702del4
2 papers
NM_003749.3
p.F228L
c.682T>C
1 paper
NM_003749.3
p.P236A
c.706C>G
1 paper
NM_003749.3
p.G227R
c.679G>C
1 paper
NM_003749.3
p.S237W
c.710C>G
1 paper
NM_003749.3
p.A223V
c.668C>T
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