Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.A180S

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.A180S
c.538G>T
Surrounding Variants
1 paper
NM_003749.3
p.G179delFs
c.536_537delCC
1 paper
NM_003749.3
p.G176S
c.526G>A
1 paper
NM_003749.3
p.A175T
c.523G>A
1 paper
NM_003749.3
p.G173S
c.517G>A
1 paper
NM_003749.3
p.V187A
c.560T>C
1 paper
NM_003749.3
p.V187delFs
c.559delC
1 paper
NM_003749.3
p.L186_A188del0
c.557_562del6
1 paper
NM_003749.3
p.V187_P189delFs
c.559_565del7
1 paper
NM_003749.3
p.A190T
c.568G>A
1 paper
NM_003749.3
p.T191M
c.572C>T
1 paper
NM_003749.3
p.G185_T191delFs
c.555_573del19
1 paper
NM_003749.3
p.A193T
c.577G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."