Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.D152H

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.D152H
c.454G>C
Surrounding Variants
1 paper
NM_003749.3
p.A149P
c.445G>C
1 paper
NM_003749.3
p.P155L
c.464C>T
2 papers
NM_003749.3
p.A157T
c.469G>A
1 paper
NM_003749.3
p.G146D
c.437G>A
1 paper
NM_003749.3
p.A158G
c.473C>G
1 paper
NM_003749.3
p.S144T
c.431G>C
1 paper
NM_003749.3
p.T140T
c.420C>G
1 paper
NM_003749.3
p.L139P
c.416T>C
1 paper
NM_003749.3
p.A165G
c.494C>G
1 paper
NM_003749.3
p.R137H
c.410G>A
1 paper
NM_003749.3
p.W135C
c.405G>C
1 paper
NM_003749.3
p.Q132L
c.395A>T
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