Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.D106Y

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.D106Y
c.316G>T
Surrounding Variants
1 paper
NM_003749.3
p.D106N
c.316G>A
1 paper
NM_003749.3
p.A107D
c.320C>A
1 paper
NM_003749.3
p.R104H
c.311G>A
1 paper
NM_003749.3
p.K103delFs
c.307delT
1 paper
NM_003749.3
p.N102K
c.306C>G
1 paper
NM_003749.3
p.N102K
c.306C>A
1 paper
NM_003749.3
p.N100S
c.299A>G
1 paper
NM_003749.3
p.L112L
c.334C>T
1 paper
NM_003749.3
p.A114T
c.340G>A
2 papers
NM_003749.3
p.A114V
c.341C>T
1 paper
NM_003749.3
p.A94T
c.280G>A
2 papers
NM_003749.3
p.V92V
c.276G>T
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