Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.A67_P68insCCA

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.A67_P68insCCA
c.199_203ins9
Surrounding Variants
1 paper
NM_003749.3
p.S66A
c.196T>G
2 papers
NM_003749.3
p.Q69E
c.205C>G
1 paper
NM_003749.3
p.Q69H
c.207A>C
1 paper
NM_003749.3
p.A62insFs
c.184dupG
1 paper
NM_003749.3
p.L73R
c.218T>G
1 paper
NM_003749.3
p.E59insFs
c.175dupG
1 paper
NM_003749.3
p.Y76_E77insCCA
c.226_230ins9
1 paper
NM_003749.3
p.Y76*
c.228C>G
1 paper
NM_003749.3
p.Y76*
c.228C>A
1 paper
NM_003749.3
p.Y76del1
c.226_227delGTA
1 paper
NM_003749.3
p.G56V
c.167G>T
1 paper
NM_003749.3
p.S78N
c.233G>A
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