integrin subunit beta 3 binding protein

NRIF3

HSU37139

TAP20

CENPR

integrin beta 3 binding protein (beta3-endonexin)

centromere protein R

beta3-endonexin

Centromere protein R

Beta-3-endonexin

Integrin beta-3-binding protein

Nuclear receptor-interacting factor 3

CENP-R

This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].

Varaico: Literature-Extracted Genetic Variants

ITGB3BP

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols