potassium voltage-gated channel interacting protein 3

CSEN

DREAM

KCHIP3

calsenilin, presenilin-binding protein, EF hand transcription factor

Kv channel interacting protein 3, calsenilin

calsenilin

DRE-antagonist modulator

Calsenilin

A-type potassium channel modulatory protein 3

Kv channel-interacting protein 3

KChIP3

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

KCNIP3

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol