alpha-ketoglutarate dehydrogenase subunit 4

MRPS36

DC47

MRP-S36

mitochondrial ribosomal protein S36

Alpha-ketoglutarate dehydrogenase component 4

Alpha-ketoglutarate dehydrogenase subunit 4

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

KGD4

RefSeq Summary

Gene Aliases

HGNC Name

HGNC Previous Symbol