Varaico: Literature-Extracted Genetic Variants

KNDC1

136 papers

RefSeq Summary

The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endot...

Pfam Domains

KINDaa 37–183UCSCKinase non-catalytic C-lobe domain

RasGEF_Naa 1249–1348UCSCRasGEF N-terminal motif

RasGEFaa 1471–1678UCSCRasGEF domain

Gene Aliases

HGNC Name

kinase non-catalytic C-lobe domain containing 1

HGNC Previous Symbols

RASGEF2; C10orf23

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_152643.8

p.Y124*

c.372C>G

Surrounding Variants

4 papers

NM_152643.8

p.A128S

c.382G>T

1 paper

NM_152643.8

p.T129M

c.386C>T

1 paper

NM_152643.8

p.A133T

c.397G>A

1 paper

NM_152643.8

p.L146_S147insFs

c.438_439insCA

1 paper

NM_152643.8

p.A152V

c.455C>T

1 paper

NM_152643.8

p.L154P

c.461T>C

1 paper

NM_152643.8

p.S155G

c.463A>G

1 paper

NM_152643.8

p.R156Q

c.467G>A

1 paper

NM_152643.8

p.G163R

c.487G>A

1 paper

NM_152643.8

p.G163R

c.487G>C

1 paper

NM_152643.8

p.D164Y

c.490G>T

1 paper

NM_152643.8

p.V187V

c.561G>A