Varaico: Literature-Extracted Genetic Variants

LATS1

253 papers

RefSeq Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is pho...

Pfam Domains

UBAaa 101–138UCSCUBA/TS-N domain

Pkinaseaa 705–866UCSCProtein kinase domain

Pkinaseaa 896–1010UCSCProtein kinase domain

Pkinase_Caa 1030–1080UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

large tumor suppressor kinase 1

HGNC Alias Symbol

WARTS

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004690.4

p.P557L

c.1670C>T

Surrounding Variants

1 paper

NM_004690.4

p.Y559F

c.1676A>T

2 papers

NM_004690.4

p.G554E

c.1661G>A

1 paper

NM_004690.4

p.Q553E

c.1657C>G

2 papers

NM_004690.4

p.N551S

c.1652A>G

3 papers

NM_004690.4

p.A549S

c.1645G>T

2 papers

NM_004690.4

p.P568L

c.1703C>T

1 paper

NM_004690.4

p.E574*

c.1720G>T

1 paper

NM_004690.4

p.N539K

c.1617T>G

1 paper

NM_004690.4

p.N539K

c.1617T>A

1 paper

NM_004690.4

p.T536N

c.1607C>A

2 papers

NM_004690.4

p.P579S

c.1735C>T

2 papers

NM_004690.4

p.G535E

c.1604G>A