Varaico: Literature-Extracted Genetic Variants

LATS1

253 papers

RefSeq Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is pho...

Pfam Domains

UBAaa 101–138UCSCUBA/TS-N domain

Pkinaseaa 705–866UCSCProtein kinase domain

Pkinaseaa 896–1010UCSCProtein kinase domain

Pkinase_Caa 1030–1080UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

large tumor suppressor kinase 1

HGNC Alias Symbol

WARTS

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004690.4

p.N361fs

c.1081_1082fs

Surrounding Variants

1 paper

NM_004690.4

p.H359L

c.1076A>T

1 paper

NM_004690.4

p.H359P

c.1076A>C

1 paper

NM_004690.4

p.A365T

c.1093G>A

2 papers

NM_004690.4

p.T367I

c.1100C>T

1 paper

NM_004690.4

p.N361_N369delFs

c.1082_1106del25

1 paper

NM_004690.4

p.R370W

c.1108C>T

1 paper

NM_004690.4

p.R370L

c.1109G>T

2 papers

NM_004690.4

p.P375S

c.1123C>T

1 paper

NM_004690.4

p.Y376C

c.1127A>G

1 paper

NM_004690.4

p.P377S

c.1129C>T

1 paper

NM_004690.4

p.A380S

c.1138G>T

1 paper

NM_004690.4

p.P341fs

c.1021_1022fs