Varaico: Literature-Extracted Genetic Variants

LATS1

253 papers

RefSeq Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is pho...

Pfam Domains

UBAaa 101–138UCSCUBA/TS-N domain

Pkinaseaa 705–866UCSCProtein kinase domain

Pkinaseaa 896–1010UCSCProtein kinase domain

Pkinase_Caa 1030–1080UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

large tumor suppressor kinase 1

HGNC Alias Symbol

WARTS

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004690.4

p.L78F

c.234G>T

Surrounding Variants

1 paper

NM_004690.4

p.L78fs

c.232_233fs

1 paper

NM_004690.4

p.L78F

c.234G>C

1 paper

NM_004690.4

p.Q79Q

c.237G>A

1 paper

NM_004690.4

p.K76I

c.227A>T

1 paper

NM_004690.4

p.I81M

c.243T>G

2 papers

NM_004690.4

p.R82*

c.244C>T

1 paper

NM_004690.4

p.R82P

c.245G>C

2 papers

NM_004690.4

p.R82Q

c.245G>A

1 paper

NM_004690.4

p.H75N

c.223C>A

1 paper

NM_004690.4

p.T73M

c.218C>T

1 paper

NM_004690.4

p.L86R

c.257T>G

1 paper

NM_004690.4

p.I81_A89delFs

c.242_266del25