Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.M1V

c.1A>G

Surrounding Variants

1 paper

NM_005356.5

p.M1insFs

c.2dupT

1 paper

NM_005356.5

p.M1T

c.2T>C

1 paper

NM_005356.5

p.M1I

c.3G>A

1 paper

NM_005356.5

p.M1_G2insFs

c.3_4insA

1 paper

NM_005356.5

p.G2C

c.4G>T

1 paper

NM_005356.5

p.E10delFs

c.28delG

1 paper

NM_005356.5

p.E10K

c.28G>A

1 paper

NM_005356.5

p.M14V

c.40A>G

1 paper

NM_005356.5

p.M14K

c.41T>A

1 paper

NM_005356.5

p.M14T

c.41T>C

1 paper

NM_005356.5

p.M14I

c.42G>A

1 paper

NM_005356.5

p.M14I

c.42G>C