Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.I17F

c.49A>T

Surrounding Variants

1 paper

NM_005356.5

p.I17V

c.49A>G

2 papers

NM_005356.5

p.I17T

c.50T>C

1 paper

NM_005356.5

p.N16fs

c.46_47fs

1 paper

NM_005356.5

p.D18N

c.52G>A

1 paper

NM_005356.5

p.N16delFs

c.47delA

1 paper

NM_005356.5

p.M14I

c.42G>A

1 paper

NM_005356.5

p.M14I

c.42G>C

1 paper

NM_005356.5

p.M14I

c.42G>T

1 paper

NM_005356.5

p.M14K

c.41T>A

1 paper

NM_005356.5

p.M14T

c.41T>C

1 paper

NM_005356.5

p.M14V

c.40A>G

1 paper

NM_005356.5

p.C20W

c.60T>G