Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.A58D

c.173C>A

Surrounding Variants

1 paper

NM_005356.5

p.S59A

c.175T>G

1 paper

NM_005356.5

p.P57L

c.170C>T

1 paper

NM_005356.5

p.P56fs

c.166_167fs

1 paper

NM_005356.5

p.P56delFs

c.167delC

1 paper

NM_005356.5

p.S54C

c.161C>G

1 paper

NM_005356.5

p.D63Y

c.187G>T

1 paper

NM_005356.5

p.T50T

c.150C>A

1 paper

NM_005356.5

p.L48Q

c.143T>A

1 paper

NM_005356.5

p.P47R

c.140C>G

2 papers

NM_005356.5

p.R45Q

c.134G>A

1 paper

NM_005356.5

p.R45W

c.133C>T

1 paper

NM_005356.5

p.R39*

c.115C>T