Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.G85W

c.253G>T

Surrounding Variants

1 paper

NM_005356.5

p.E86K

c.256G>A

1 paper

NM_005356.5

p.G81D

c.242G>A

2 papers

NM_005356.5

p.L80V

c.238C>G

1 paper

NM_005356.5

p.L91L

c.271C>T

1 paper

NM_005356.5

p.D77Y

c.229G>T

1 paper

NM_005356.5

p.Q93Splc

c.278+2T>G

1 paper

NM_005356.5

p.P74P

c.222C>T

2 papers

NM_005356.5

p.P74L

c.221C>T

1 paper

NM_005356.5

p.I67I

c.201C>T

2 papers

NM_005356.5

p.V66A

c.197T>C

1 paper

NM_005356.5

p.L65_V66insFs

c.195_196insT

5 papers

NM_005356.5

p.D63Splc

c.188-2A>G