Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.E176Q

c.526G>C

Surrounding Variants

1 paper

NM_005356.5

p.E176V

c.527A>T

1 paper

NM_005356.5

p.G175V

c.524G>T

1 paper

NM_005356.5

p.N173D

c.517A>G

1 paper

NM_005356.5

p.H180D

c.538C>G

1 paper

NM_005356.5

p.V167I

c.499G>A

1 paper

NM_005356.5

p.S166L

c.497C>T

1 paper

NM_005356.5

p.L165L

c.493C>T

1 paper

NM_005356.5

p.D187N

c.559G>A

1 paper

NM_005356.5

p.D187G

c.560A>G

1 paper

NM_005356.5

p.N188delFs

c.562delA

2 papers

NM_005356.5

p.Y192F

c.575A>T

1 paper

NM_005356.5

p.P195_R196insT

c.583_587ins3