Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.V325A

c.974T>C

Surrounding Variants

1 paper

NM_005356.5

p.D326A

c.977A>C

1 paper

NM_005356.5

p.F327delFs

c.981delT

1 paper

NM_005356.5

p.F327V

c.979T>G

1 paper

NM_005356.5

p.L328fs

c.982_983fs

1 paper

NM_005356.5

p.T330P

c.988A>C

1 paper

NM_005356.5

p.G333D

c.998G>A

1 paper

NM_005356.5

p.I334S

c.1001T>G

1 paper

NM_005356.5

p.K335Fs

c.1003delinsGAFs

1 paper

NM_005356.5

p.L336L

c.1006T>C

1 paper

NM_005356.5

p.I338I

c.1014C>T

1 paper

NM_005356.5

p.N339S

c.1016A>G

13 papers

NM_005356.5

p.L341P

c.1022T>C