Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.Y360H

c.1078T>C

Surrounding Variants

1 paper

NM_005356.5

p.R358W

c.1072C>T

1 paper

NM_005356.5

p.H362Q

c.1086T>A

1 paper

NM_005356.5

p.H362Q

c.1086T>G

1 paper

NM_005356.5

p.R363C

c.1087C>T

1 paper

NM_005356.5

p.E356D

c.1068A>C

1 paper

NM_005356.5

p.E356D

c.1068A>T

1 paper

NM_005356.5

p.E356A

c.1067A>C

1 paper

NM_005356.5

p.F354L

c.1062C>A

1 paper

NM_005356.5

p.F354L

c.1062C>G

1 paper

NM_005356.5

p.A367delFs

c.1099delG

1 paper

NM_005356.5

p.F354L

c.1060T>C

3 papers

NM_005356.5

p.A353V

c.1058C>T