Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.K379N

c.1137G>C

Surrounding Variants

1 paper

NM_005356.5

p.K379N

c.1137G>T

1 paper

NM_005356.5

p.S377fs

c.1129_1130fs

1 paper

NM_005356.5

p.D382E

c.1146C>A

1 paper

NM_005356.5

p.D382E

c.1146C>G

3 papers

NM_005356.5

p.S377insFs

c.1129dupA

1 paper

NM_005356.5

p.L376P

c.1127T>C

1 paper

NM_005356.5

p.D374H

c.1120G>C

1 paper

NM_005356.5

p.R387C

c.1159C>T

2 papers

NM_005356.5

p.L388F

c.1162C>T

1 paper

NM_005356.5

p.I370V

c.1108A>G

1 paper

NM_005356.5

p.A367fs

c.1099_1100fs

1 paper

NM_005356.5

p.E393G

c.1178A>G