Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.T407A

c.1219A>G

Surrounding Variants

1 paper

NM_005356.5

p.T407S

c.1219A>T

1 paper

NM_005356.5

p.T407R

c.1220C>G

1 paper

NM_005356.5

p.T407I

c.1220C>T

1 paper

NM_005356.5

p.P409Q

c.1226C>A

1 paper

NM_005356.5

p.P409L

c.1226C>T

1 paper

NM_005356.5

p.P403P

c.1209C>T

1 paper

NM_005356.5

p.I412F

c.1234A>T

1 paper

NM_005356.5

p.G399E

c.1196G>A

1 paper

NM_005356.5

p.G415R

c.1243G>A

1 paper

NM_005356.5

p.G399Splc

c.1196-1G>C

1 paper

NM_005356.5

p.G415R

c.1243G>C

1 paper

NM_005356.5

p.T416K

c.1247C>A