Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.E448K

c.1342G>A

Surrounding Variants

2 papers

NM_005356.5

p.P447R

c.1340C>G

4 papers

NM_005356.5

p.P447L

c.1340C>T

1 paper

NM_005356.5

p.P447A

c.1339C>G

2 papers

NM_005356.5

p.N446K

c.1338C>A

2 papers

NM_005356.5

p.N446K

c.1338C>G

1 paper

NM_005356.5

p.Q451E

c.1351C>G

1 paper

NM_005356.5

p.R455Q

c.1364G>A

1 paper

NM_005356.5

p.R458S

c.1372C>A

1 paper

NM_005356.5

p.R458H

c.1373G>A

3 papers

NM_005356.5

p.C465R

c.1393T>C

1 paper

NM_005356.5

p.P466L

c.1397C>T

1 paper

NM_005356.5

p.L469M

c.1405C>A