Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.L472H

c.1415T>A

Surrounding Variants

1 paper

NM_005356.5

p.L472P

c.1415T>C

1 paper

NM_005356.5

p.M473I

c.1419G>A

1 paper

NM_005356.5

p.M473I

c.1419G>C

1 paper

NM_005356.5

p.M473I

c.1419G>T

1 paper

NM_005356.5

p.L469M

c.1405C>A

1 paper

NM_005356.5

p.W477*

c.1430G>A

1 paper

NM_005356.5

p.W477*

c.1431G>A

1 paper

NM_005356.5

p.P466L

c.1397C>T

3 papers

NM_005356.5

p.C465R

c.1393T>C

1 paper

NM_005356.5

p.R480fs

c.1438_1439fs

1 paper

NM_005356.5

p.P481S

c.1441C>T

1 paper

NM_005356.5

p.P481L

c.1442C>T