Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.Y489F

c.1466A>T

Surrounding Variants

1 paper

NM_005356.5

p.R491H

c.1472G>A

1 paper

NM_005356.5

p.F487S

c.1460T>C

1 paper

NM_005356.5

p.T486S

c.1457C>G

1 paper

NM_005356.5

p.T486S

c.1456A>T

1 paper

NM_005356.5

p.D483G

c.1448A>G

1 paper

NM_005356.5

p.F497I

c.1489T>A

1 paper

NM_005356.5

p.P481L

c.1442C>T

1 paper

NM_005356.5

p.P481S

c.1441C>T

1 paper

NM_005356.5

p.R480fs

c.1438_1439fs

2 papers

NM_005356.5

p.T499M

c.1496C>T

1 paper

NM_005356.5

p.A500T

c.1498G>A

1 paper

NM_005356.5

p.W477*

c.1431G>A