Varaico: Literature-Extracted Genetic Variants

LEF1

243 papers

RefSeq Summary

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally impor...

Pfam Domains

CTNNB1_bindingaa 9–213UCSCN-terminal CTNNB1 binding

HMG_boxaa 299–367UCSCHMG (high mobility group) box

Gene Aliases

HGNC Name

lymphoid enhancer binding factor 1

HGNC Alias Symbols

TCF1ALPHA; TCF10; TCF7L3

Papers

RefSeq ID

Protein change

DNA change

1–12 of 161 variants

6 papers

NM_016269.5

p.D85N

c.253G>A

6 papers

NM_016269.5

p.P106L

c.317C>T

4 papers

NM_016269.5

p.K86E

c.256A>G

4 papers

NM_016269.5

p.E385K

c.1153G>A

3 papers

NM_016269.5

p.S61P

c.181T>C

3 papers

NM_016269.5

p.G113R

c.337G>C

3 papers

NM_016269.5

p.G113R

c.337G>A

3 papers

NM_016269.5

p.V282M

c.844G>A

3 papers

NM_016269.5

p.V282M

c.844G>A

3 papers

NM_016269.5

p.V318fs

c.952_953fs

3 papers

NM_016269.5

p.V318insFs

c.952_953ins5

3 papers

NM_016269.5

p.R353Q

c.1058G>A