Varaico: Literature-Extracted Genetic Variants

LEF1

243 papers

RefSeq Summary

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally impor...

Pfam Domains

CTNNB1_bindingaa 9–213UCSCN-terminal CTNNB1 binding

HMG_boxaa 299–367UCSCHMG (high mobility group) box

Gene Aliases

HGNC Name

lymphoid enhancer binding factor 1

HGNC Alias Symbols

TCF1ALPHA; TCF10; TCF7L3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_016269.5

p.E385K

c.1153G>A

Surrounding Variants

1 paper

NM_016269.5

p.S386P

c.1156T>C

1 paper

NM_016269.5

p.K376N

c.1128G>T

1 paper

NM_016269.5

p.K376N

c.1128G>C

1 paper

NM_016269.5

p.A368T

c.1102G>A

3 papers

NM_016269.5

p.R353Q

c.1058G>A

1 paper

NM_016269.5

p.W337*

c.1011G>A

1 paper

NM_016269.5

p.W337*

c.1010G>A