Varaico: Literature-Extracted Genetic Variants

LEF1

243 papers

RefSeq Summary

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally impor...

Pfam Domains

CTNNB1_bindingaa 9–213UCSCN-terminal CTNNB1 binding

HMG_boxaa 299–367UCSCHMG (high mobility group) box

Gene Aliases

HGNC Name

lymphoid enhancer binding factor 1

HGNC Alias Symbols

TCF1ALPHA; TCF10; TCF7L3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_016269.5

p.P284L

c.851C>T

Surrounding Variants

1 paper

NM_016269.5

p.Q285K

c.853C>A

1 paper

NM_016269.5

p.H286delFs

c.856delG

3 papers

NM_016269.5

p.V282M

c.844G>A

1 paper

NM_016269.5

p.P294R

c.881C>G

1 paper

NM_016269.5

p.R296S

c.888A>T

1 paper

NM_016269.5

p.R296S

c.888A>C

1 paper

NM_016269.5

p.I299insFs

c.896_897ins4

1 paper

NM_016269.5

p.K300fs

c.898_899fs

1 paper

NM_016269.5

p.P302S

c.904C>T

1 paper

NM_016269.5

p.N304H

c.910A>C

1 paper

NM_016269.5

p.Y309_K311del3

c.925_932del9

1 paper

NM_016269.5

p.V317A

c.950T>C