Varaico: Literature-Extracted Genetic Variants

LEF1

243 papers

RefSeq Summary

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally impor...

Pfam Domains

CTNNB1_bindingaa 9–213UCSCN-terminal CTNNB1 binding

HMG_boxaa 299–367UCSCHMG (high mobility group) box

Gene Aliases

HGNC Name

lymphoid enhancer binding factor 1

HGNC Alias Symbols

TCF1ALPHA; TCF10; TCF7L3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_016269.5

p.Q270*

c.808C>T

Surrounding Variants

1 paper

NM_016269.5

p.V264_T265insFs

c.792_793insC

1 paper

NM_016269.5

p.H281H

c.843C>T

3 papers

NM_016269.5

p.V282M

c.844G>A

1 paper

NM_016269.5

p.G257V

c.770G>T

1 paper

NM_016269.5

p.P253P

c.759C>A

1 paper

NM_016269.5

p.G252D

c.755G>A

1 paper

NM_016269.5

p.G249S

c.745G>A

3 papers

NM_016269.5

p.V282M

c.844G>A

1 paper

NM_016269.5

p.P284L

c.851C>T

1 paper

NM_016269.5

p.Q285K

c.853C>A

1 paper

NM_016269.5

p.H286delFs

c.856delG

1 paper

NM_016269.5

p.P294R

c.881C>G