Varaico: Literature-Extracted Genetic Variants

LEF1

243 papers

RefSeq Summary

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally impor...

Pfam Domains

CTNNB1_bindingaa 9–213UCSCN-terminal CTNNB1 binding

HMG_boxaa 299–367UCSCHMG (high mobility group) box

Gene Aliases

HGNC Name

lymphoid enhancer binding factor 1

HGNC Alias Symbols

TCF1ALPHA; TCF10; TCF7L3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_016269.5

p.D93V

c.278A>T

Surrounding Variants

1 paper

NM_016269.5

p.D92H

c.274G>C

1 paper

NM_016269.5

p.D92N

c.274G>A

4 papers

NM_016269.5

p.K86E

c.256A>G

6 papers

NM_016269.5

p.D85N

c.253G>A

1 paper

NM_016269.5

p.P82insFs

c.246dupC

1 paper

NM_016269.5

p.Y83fs

c.247_248fs

1 paper

NM_016269.5

p.Q77_E81delFs

c.230_242del13

2 papers

NM_016269.5

p.E81V

c.242A>T

1 paper

NM_016269.5

p.Q77_T78delFs

c.230_233del4

1 paper

NM_016269.5

p.A73delFs

c.219delG

1 paper

NM_016269.5

p.A73A

c.219C>T

1 paper

NM_016269.5

p.A73insFs

c.218_219insG