Varaico: Literature-Extracted Genetic Variants

Gene:LEFTY1
Variant:p.W281R

LEFTY1

63 papers

RefSeq Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activat...

Pfam Domains

TGFb_propeptideaa 24–224UCSCTGF-beta propeptide
TGF_betaaa 262–353UCSCTransforming growth factor beta like domain

Gene Aliases

HGNC Name

left-right determination factor 1

HGNC Previous Symbol

LEFTB

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_020997.4
p.W281R
c.841T>A
Surrounding Variants
2 papers
NM_020997.4
p.W281R
c.841T>C
1 paper
NM_020997.4
p.E279E
c.837G>A
1 paper
NM_020997.4
p.W277C
c.831G>T
1 paper
NM_020997.4
p.W277C
c.831G>C
1 paper
NM_020997.4
p.P286Q
c.857C>A
1 paper
NM_020997.4
p.Y291*
c.873T>G
1 paper
NM_020997.4
p.Y291*
c.873T>A
1 paper
NM_020997.4
p.C297F
c.890G>T
1 paper
NM_020997.4
p.R298Q
c.893G>A
1 paper
NM_020997.4
p.E259K
c.775G>A
1 paper
NM_020997.4
p.G312R
c.934G>C
1 paper
NM_020997.4
p.G312R
c.934G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."