Varaico: Literature-Extracted Genetic Variants

Gene:LEP
Variant:p.I35I

LEP

798 papers

RefSeq Summary

This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in...

Pfam Domains

Leptinaa 23–167UCSCLeptin

Gene Aliases

HGNC Name

leptin

HGNC Previous Symbols

OBS; OB

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
6 papers
NM_000230.3
p.I35I
c.105C>T
Surrounding Variants
2 papers
NM_000230.3
p.I35I
c.105C>A
1 paper
NM_000230.3
p.K36E
c.106A>G
10 papers
NM_000230.3
p.I35S
c.104T>G
4 papers
NM_000230.3
p.K36R
c.107A>G
1 paper
NM_000230.3
p.L34L
c.102C>T
1 paper
NM_000230.3
p.L34I
c.100C>A
4 papers
NM_000230.3
p.L34F
c.100C>T
19 papers
NM_000230.3
p.I35_K36del1
c.104_106delTCA
1 paper
NM_000230.3
p.T37T
c.111A>G
1 paper
NM_000230.3
p.I38V
c.112A>G
1 paper
NM_000230.3
p.T33N
c.98C>A
2 papers
NM_000230.3
p.T33I
c.98C>T
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