Varaico: Literature-Extracted Genetic Variants

Gene:LEP
Variant:p.D76G

LEP

798 papers

RefSeq Summary

This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in...

Pfam Domains

Leptinaa 23–167UCSCLeptin

Gene Aliases

HGNC Name

leptin

HGNC Previous Symbols

OBS; OB

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_000230.3
p.D76G
c.227A>G
Surrounding Variants
3 papers
NM_000230.3
p.D76V
c.227A>T
5 papers
NM_000230.3
p.M75V
c.223A>G
1 paper
NM_000230.3
p.Q77Q
c.231G>A
1 paper
NM_000230.3
p.T78A
c.232A>G
1 paper
NM_000230.3
p.T78S
c.232A>T
1 paper
NM_000230.3
p.K74K
c.222G>A
1 paper
NM_000230.3
p.T78K
c.233C>A
1 paper
NM_000230.3
p.T78I
c.233C>T
1 paper
NM_000230.3
p.T78T
c.234A>C
1 paper
NM_000230.3
p.L79L
c.235C>T
1 paper
NM_000230.3
p.S73F
c.218C>T
1 paper
NM_000230.3
p.S73P
c.217T>C
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