Varaico: Literature-Extracted Genetic Variants

Gene:LEP
Variant:p.W121*

LEP

798 papers

RefSeq Summary

This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in...

Pfam Domains

Leptinaa 23–167UCSCLeptin

Gene Aliases

HGNC Name

leptin

HGNC Previous Symbols

OBS; OB

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
12 papers
NM_000230.3
p.W121*
c.363G>A
Surrounding Variants
1 paper
NM_000230.3
p.W121C
c.363G>C
12 papers
NM_000230.3
p.W121*
c.362G>A
1 paper
NM_000230.3
p.A122P
c.364G>C
2 papers
NM_000230.3
p.P120P
c.360C>G
1 paper
NM_000230.3
p.P120P
c.360C>T
1 paper
NM_000230.3
p.S123G
c.367A>G
1 paper
NM_000230.3
p.S123S
c.369T>C
1 paper
NM_000230.3
p.L119V
c.355T>G
13 papers
NM_000230.3
p.H118L
c.353A>T
1 paper
NM_000230.3
p.L125L
c.373C>T
1 paper
NM_000230.3
p.H118Y
c.352C>T
1 paper
NM_000230.3
p.C117C
c.351C>T
UCSC Genome Browser·Imprint·Privacy·Terms·Feedback·Email Updates·

Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."