Varaico: Literature-Extracted Genetic Variants

LIFR

293 papers

RefSeq Summary

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the actio...

Pfam Domains

LIFR_Naa 51–129UCSCLeukemia inhibitory factor receptor N-terminal domain

LIFR_D2aa 131–244UCSCLeukemia inhibitory factor receptor D2 domain

LIF-R_Ig-likeaa 254–330UCSCLeukemia inhibitory factor receptor, Ig-like domain

LIFR_D4aa 332–430UCSCLeukemia inhibitory factor receptor D4 domain

fn3aa 434–526UCSCFibronectin type III domain

Gene Aliases

HGNC Name

LIF receptor subunit alpha

HGNC Alias Symbol

CD118

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_001127671.2

p.S279P

c.835T>C

Surrounding Variants

1 paper

NM_001127671.2

p.K276insFs

c.828dupA

1 paper

NM_001127671.2

p.V277fs

c.829_830fs

4 papers

NM_001127671.2

p.I282T

c.845T>C

1 paper

NM_001127671.2

p.E275*

c.823G>T

1 paper

NM_001127671.2

p.T268A

c.802A>G

1 paper

NM_001127671.2

p.D266N

c.796G>A

2 papers

NM_001127671.2

p.L292P

c.875T>C

1 paper

NM_001127671.2

p.G264S

c.790G>A

1 paper

NM_001127671.2

p.N303D

c.907A>G

1 paper

NM_001127671.2

p.S305T

c.913T>A

7 papers

NM_001127671.2

p.K253*

c.757A>T

10 papers

NM_001127671.2

p.T252insFs

c.756dupT