Varaico: Literature-Extracted Genetic Variants

LRRK2

4,517 papers

RefSeq Summary

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain,...

Pfam Domains

ARM_LRRK2aa 17–649UCSCLRRK2 ARM repeat

ANK_LRRK2aa 679–808UCSCLRRK2 ANK repeat

LRR_8aa 1011–1070UCSCLeucine rich repeat

Rocaa 1336–1455UCSCRas of Complex, Roc, domain of DAPkinase

COR-Aaa 1524–1673UCSCC-terminal of Roc, COR-A domain

COR-Baa 1688–1858UCSCC-terminal of Roc, COR-B domain

Gene Aliases

HGNC Name

leucine rich repeat kinase 2

HGNC Previous Symbol

PARK8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_198578.4

p.G1837R

c.5509G>A

Surrounding Variants

1 paper

NM_198578.4

p.G1837R

c.5509G>C

1 paper

NM_198578.4

p.E1835*

c.5503G>T

1 paper

NM_198578.4

p.K1832T

c.5495A>C

2 papers

NM_198578.4

p.G1837Splc

c.5509+26G>A

7 papers

NM_198578.4

p.Q1823K

c.5467C>A

4 papers

NM_198578.4

p.H1822R

c.5465A>G

17 papers

NM_198578.4

p.G1819G

c.5457T>C

2 papers

NM_198578.4

p.G1819A

c.5456G>C

1 paper

NM_198578.4

p.D1818E

c.5454T>A

1 paper

NM_198578.4

p.D1818E

c.5454T>G

1 paper

NM_198578.4

p.F1816Y

c.5447T>A

2 papers

NM_198578.4

p.A1812V

c.5435C>T