Varaico: Literature-Extracted Genetic Variants

LRRK2

4,517 papers

RefSeq Summary

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain,...

Pfam Domains

ARM_LRRK2aa 17–649UCSCLRRK2 ARM repeat

ANK_LRRK2aa 679–808UCSCLRRK2 ANK repeat

LRR_8aa 1011–1070UCSCLeucine rich repeat

Rocaa 1336–1455UCSCRas of Complex, Roc, domain of DAPkinase

COR-Aaa 1524–1673UCSCC-terminal of Roc, COR-A domain

COR-Baa 1688–1858UCSCC-terminal of Roc, COR-B domain

Gene Aliases

HGNC Name

leucine rich repeat kinase 2

HGNC Previous Symbol

PARK8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_198578.4

p.G2037R

c.6109G>C

Surrounding Variants

1 paper

NM_198578.4

p.G2037R

c.6109G>A

1 paper

NM_198578.4

p.G2037W

c.6109G>T

1 paper

NM_198578.4

p.P2036P

c.6108A>G

2 papers

NM_198578.4

p.P2036S

c.6106C>T

8 papers

NM_198578.4

p.T2035A

c.6103A>G

1 paper

NM_198578.4

p.G2034C

c.6100G>T

1 paper

NM_198578.4

p.E2033E

c.6099G>A

1 paper

NM_198578.4

p.S2032P

c.6094T>C

7 papers

NM_198578.4

p.S2032A

c.6094T>G

4 papers

NM_198578.4

p.T2031A

c.6091A>G

40 papers

NM_198578.4

p.T2031S

c.6091A>T

1 paper

NM_198578.4

p.I2029I

c.6087A>T