Varaico: Literature-Extracted Genetic Variants

LTK

168 papers

RefSeq Summary

The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading t...

Pfam Domains

ALK_LTK_GRDaa 113–383UCSCALK/LTK, Glycine-rich domain

PK_Tyr_Ser-Thraa 510–777UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

leukocyte receptor tyrosine kinase

HGNC Alias Symbol

TYK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_002344.6

p.D681delFs

c.2041delC

Surrounding Variants

2 papers

NM_002344.6

p.D681Y

c.2041G>T

2 papers

NM_002344.6

p.D681fs

c.2041_2042fs

2 papers

NM_002344.6

p.R682W

c.2044C>T

2 papers

NM_002344.6

p.R682Q

c.2045G>A

4 papers

NM_002344.6

p.A683S

c.2047G>T

1 paper

NM_002344.6

p.R679S

c.2037G>T

1 paper

NM_002344.6

p.R679S

c.2037G>C

1 paper

NM_002344.6

p.R679T

c.2036G>C

1 paper

NM_002344.6

p.R678P

c.2033G>C

1 paper

NM_002344.6

p.R678H

c.2033G>A

2 papers

NM_002344.6

p.R678C

c.2032C>T

2 papers

NM_002344.6

p.L685F

c.2053C>T