Varaico: Literature-Extracted Genetic Variants

LTK

168 papers

RefSeq Summary

The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading t...

Pfam Domains

ALK_LTK_GRDaa 113–383UCSCALK/LTK, Glycine-rich domain

PK_Tyr_Ser-Thraa 510–777UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

leukocyte receptor tyrosine kinase

HGNC Alias Symbol

TYK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_002344.6

p.K544M

c.1631A>T

Surrounding Variants

1 paper

NM_002344.6

p.K544R

c.1631A>G

3 papers

NM_002344.6

p.V541I

c.1621G>A

5 papers

NM_002344.6

p.D535N

c.1603G>A

1 paper

NM_002344.6

p.P533L

c.1598C>T

1 paper

NM_002344.6

p.G527E

c.1580G>A

1 paper

NM_002344.6

p.G527R

c.1579G>C

1 paper

NM_002344.6

p.G527R

c.1579G>A

1 paper

NM_002344.6

p.Y525*

c.1575T>G

1 paper

NM_002344.6

p.Y525*

c.1575T>A

1 paper

NM_002344.6

p.V524M

c.1570G>A

1 paper

NM_002344.6

p.G519D

c.1556G>A

1 paper

NM_002344.6

p.G517D

c.1550G>A