Varaico: Literature-Extracted Genetic Variants

LTK

168 papers

RefSeq Summary

The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading t...

Pfam Domains

ALK_LTK_GRDaa 113–383UCSCALK/LTK, Glycine-rich domain

PK_Tyr_Ser-Thraa 510–777UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

leukocyte receptor tyrosine kinase

HGNC Alias Symbol

TYK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002344.6

p.P252L

c.755C>T

Surrounding Variants

1 paper

NM_002344.6

p.R243_R247del5

c.727_740del15

1 paper

NM_002344.6

p.R243_R247delFs

c.727_740del14

1 paper

NM_002344.6

p.R247W

c.739C>T

1 paper

NM_002344.6

p.R258H

c.773G>A

1 paper

NM_002344.6

p.R245Q

c.734G>A

1 paper

NM_002344.6

p.S259L

c.776C>T

4 papers

NM_002344.6

p.R243Q

c.728G>A

1 paper

NM_002344.6

p.A261A

c.783G>T

1 paper

NM_002344.6

p.R243W

c.727C>T

4 papers

NM_002344.6

p.S264C

c.790A>T

2 papers

NM_002344.6

p.L240V

c.718C>G

1 paper

NM_002344.6

p.G265R

c.793G>C