Varaico: Literature-Extracted Genetic Variants

LYN

213 papers

RefSeq Summary

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding differ...

Pfam Domains

SH3_1aa 69–115UCSCSH3 domain

SH2aa 129–211UCSCSH2 domain

PK_Tyr_Ser-Thraa 247–497UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LYN proto-oncogene, Src family tyrosine kinase

HGNC Alias Symbol

JTK8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002350.4

p.K181M

c.542A>T

Surrounding Variants

1 paper

NM_002350.4

p.K181*

c.541A>T

1 paper

NM_002350.4

p.P174R

c.521C>G

1 paper

NM_002350.4

p.P174T

c.520C>A

3 papers

NM_002350.4

p.D189Y

c.565G>T

1 paper

NM_002350.4

p.S196F

c.587C>T

1 paper

NM_002350.4

p.P197S

c.589C>T

1 paper

NM_002350.4

p.R198*

c.592C>T

1 paper

NM_002350.4

p.R198Q

c.593G>A

1 paper

NM_002350.4

p.G163E

c.488G>A

1 paper

NM_002350.4

p.T200A

c.598A>G

1 paper

NM_002350.4

p.P202S

c.604C>T

2 papers

NM_002350.4

p.K209N

c.627A>C