Varaico: Literature-Extracted Genetic Variants

LYN

213 papers

RefSeq Summary

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding differ...

Pfam Domains

SH3_1aa 69–115UCSCSH3 domain

SH2aa 129–211UCSCSH2 domain

PK_Tyr_Ser-Thraa 247–497UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LYN proto-oncogene, Src family tyrosine kinase

HGNC Alias Symbol

JTK8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_002350.4

p.I227V

c.679A>G

Surrounding Variants

1 paper

NM_002350.4

p.K230R

c.689A>G

1 paper

NM_002350.4

p.K233insFs

c.697_698insGC

1 paper

NM_002350.4

p.C219W

c.657C>G

1 paper

NM_002350.4

p.D236N

c.706G>A

1 paper

NM_002350.4

p.W240C

c.720G>C

1 paper

NM_002350.4

p.W240C

c.720G>T

1 paper

NM_002350.4

p.S246S

c.738C>A

1 paper

NM_002350.4

p.I247_K248insC

c.739_743ins3

1 paper

NM_002350.4

p.G254insFs

c.760_761insGC

1 paper

NM_002350.4

p.G254fs

c.760_761fs

1 paper

NM_002350.4

p.A255T

c.763G>A

1 paper

NM_002350.4

p.F258L

c.772T>C