Varaico: Literature-Extracted Genetic Variants

LYN

213 papers

RefSeq Summary

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding differ...

Pfam Domains

SH3_1aa 69–115UCSCSH3 domain

SH2aa 129–211UCSCSH2 domain

PK_Tyr_Ser-Thraa 247–497UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LYN proto-oncogene, Src family tyrosine kinase

HGNC Alias Symbol

JTK8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_002350.4

p.D385Y

c.1153G>T

Surrounding Variants

2 papers

NM_002350.4

p.D385G

c.1154A>G

1 paper

NM_002350.4

p.C381*

c.1143C>A

1 paper

NM_002350.4

p.C381Y

c.1142G>A

1 paper

NM_002350.4

p.M380fs

c.1138_1139fs

1 paper

NM_002350.4

p.V391I

c.1171G>A

1 paper

NM_002350.4

p.Y397D

c.1189T>G

1 paper

NM_002350.4

p.Y397C

c.1190A>G

1 paper

NM_002350.4

p.Y397F

c.1190A>T

1 paper

NM_002350.4

p.Y397*

c.1191C>A

1 paper

NM_002350.4

p.Y397*

c.1191C>G

1 paper

NM_002350.4

p.A371V

c.1112C>T

1 paper

NM_002350.4

p.A399S

c.1195G>T