Varaico: Literature-Extracted Genetic Variants

LYN

213 papers

RefSeq Summary

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding differ...

Pfam Domains

SH3_1aa 69–115UCSCSH3 domain

SH2aa 129–211UCSCSH2 domain

PK_Tyr_Ser-Thraa 247–497UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LYN proto-oncogene, Src family tyrosine kinase

HGNC Alias Symbol

JTK8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_002350.4

p.E435K

c.1303G>A

Surrounding Variants

1 paper

NM_002350.4

p.E435G

c.1304A>G

1 paper

NM_002350.4

p.Y434Y

c.1302C>T

1 paper

NM_002350.4

p.I436V

c.1306A>G

1 paper

NM_002350.4

p.L432F

c.1294C>T

1 paper

NM_002350.4

p.W427C

c.1281G>C

1 paper

NM_002350.4

p.W427C

c.1281G>T

2 papers

NM_002350.4

p.P443S

c.1327C>T

1 paper

NM_002350.4

p.D425A

c.1274A>C

1 paper

NM_002350.4

p.K423K

c.1269G>A

1 paper

NM_002350.4

p.C419Y

c.1256G>A

1 paper

NM_002350.4

p.C419F

c.1256G>T

1 paper

NM_002350.4

p.G418R

c.1252G>A