Varaico: Literature-Extracted Genetic Variants

Gene:MAP2K1
Variant:p.P105S

MAP2K1

1,996 papers

RefSeq Summary

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular sign...

Pfam Domains

Pkinaseaa 46–127UCSCProtein kinase domain
Pkinaseaa 123–313UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase 1

HGNC Previous Symbol

PRKMK1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_002755.4
p.P105S
c.313C>T
Surrounding Variants
2 papers
NM_002755.4
p.P105_I107del0
c.314_319del6
2 papers
NM_002755.4
p.K104N
c.312A>C
2 papers
NM_002755.4
p.K104N
c.312A>T
1 paper
NM_002755.4
p.P105_I107del3
c.313_320del9
1 paper
NM_002755.4
p.A106_I107del0
c.316_321del6
1 paper
NM_002755.4
p.P105_I107delins
c.314_320delinsG
1 paper
NM_002755.4
p.K104I
c.311A>T
4 papers
NM_002755.4
p.P105_A106del0
c.313_318del6
1 paper
NM_002755.4
p.P105P
c.315C>T
1 paper
NM_002755.4
p.A106del1
c.316_317delGCA
2 papers
NM_002755.4
p.K104Q
c.310A>C
1 paper
NM_002755.4
p.K104*
c.310A>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."