Varaico: Literature-Extracted Genetic Variants

Gene:MAP2K1
Variant:p.R108W

MAP2K1

1,996 papers

RefSeq Summary

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular sign...

Pfam Domains

Pkinaseaa 46–127UCSCProtein kinase domain
Pkinaseaa 123–313UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase 1

HGNC Previous Symbol

PRKMK1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
4 papers
NM_002755.4
p.R108W
c.322C>T
Surrounding Variants
7 papers
NM_002755.4
p.R108Q
c.323G>A
5 papers
NM_002755.4
p.R108L
c.323G>T
1 paper
NM_002755.4
p.I107fs
c.319_320fs
1 paper
NM_002755.4
p.I107L
c.319A>C
1 paper
NM_002755.4
p.I107V
c.319A>G
1 paper
NM_002755.4
p.N109K
c.327C>A
1 paper
NM_002755.4
p.N109K
c.327C>G
2 papers
NM_002755.4
p.A106V
c.317C>T
9 papers
NM_002755.4
p.A106T
c.316G>A
1 paper
NM_002755.4
p.A106S
c.316G>T
1 paper
NM_002755.4
p.P105P
c.315C>T
1 paper
NM_002755.4
p.A106del1
c.316_317delGCA
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."