Varaico: Literature-Extracted Genetic Variants

Gene:MAP2K1
Variant:p.F133L

MAP2K1

1,996 papers

RefSeq Summary

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular sign...

Pfam Domains

Pkinaseaa 46–127UCSCProtein kinase domain
Pkinaseaa 123–313UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase 1

HGNC Previous Symbol

PRKMK1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
3 papers
NM_002755.4
p.F133L
c.399C>A
Surrounding Variants
3 papers
NM_002755.4
p.F133L
c.399C>G
2 papers
NM_002755.4
p.Y134H
c.400T>C
13 papers
NM_002755.4
p.Y134C
c.401A>G
1 paper
NM_002755.4
p.Y134F
c.401A>T
3 papers
NM_002755.4
p.F133L
c.397T>C
1 paper
NM_002755.4
p.F133V
c.397T>G
5 papers
NM_002755.4
p.A132V
c.395C>T
1 paper
NM_002755.4
p.S135T
c.404G>C
2 papers
NM_002755.4
p.A132S
c.394G>T
1 paper
NM_002755.4
p.A132fs
c.394_395fs
1 paper
NM_002755.4
p.S135S
c.405C>T
1 paper
NM_002755.4
p.D136del1
c.406_407delGAT
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."