Varaico: Literature-Extracted Genetic Variants

Gene:MAP2K1
Variant:p.M143V

MAP2K1

1,996 papers

RefSeq Summary

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular sign...

Pfam Domains

Pkinaseaa 46–127UCSCProtein kinase domain
Pkinaseaa 123–313UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase 1

HGNC Previous Symbol

PRKMK1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
3 papers
NM_002755.4
p.M143V
c.427A>G
Surrounding Variants
1 paper
NM_002755.4
p.C142Y
c.425G>A
3 papers
NM_002755.4
p.E144K
c.430G>A
1 paper
NM_002755.4
p.E144Q
c.430G>C
1 paper
NM_002755.4
p.I141S
c.422T>G
1 paper
NM_002755.4
p.H145Y
c.433C>T
1 paper
NM_002755.4
p.H145P
c.434A>C
1 paper
NM_002755.4
p.S140I
c.419G>T
5 papers
NM_002755.4
p.M146I
c.438G>A
5 papers
NM_002755.4
p.M146I
c.438G>C
5 papers
NM_002755.4
p.M146I
c.438G>T
1 paper
NM_002755.4
p.I139T
c.416T>C
2 papers
NM_002755.4
p.M146_D147Splc
c.438+1G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."